Mutants continue their struggle against a scoiety that fears and distrusts them. Their cause becomes even more desperate following an incredible attack by an as yet undetermined assailent possesing extraordinary skills. The shocking attack renews the political and public outcry for mutant registrastion act, and an anti-mutant movement, now lead by Joseph Stryker, a wealthy former army commander whio is rumoured to have experimented on mutants.

 

Strykers mutant work is somehow linked to Wolverine's mysterious and forgotten past. As Wolverine searches for clues to his origin, Stryker puts into motion his anti-mutant program, launching an attck on Xavier's mansion. Magneto, newly escaped from his Plastic Prison, proposes a partnership with the X-men to combat their common and formidable enemy: Joseph Stryker.

 

With the fates of Xavier, mankind - and mutantkind - in their hands, the X-men face their most difficult mission ever.